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0 to 55. 615Å O C 1. 212 Scheme 6 Reagents: (a) PhSH or PrSHKOH; (b) C1C6H4CO2OH or CH3CO2OH; (c) Ra- NiPd-C, H2; (d) H; (e) MeS-C(NCOOMe)NHCOOMe or other cyclising agents. Histamine H3 binding data for GT-2016 derivatives Figure 7 shows an overlay of the energy minimized structures for each of the compounds in Table 1.

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